EMD-386088 is an indole derivative which is used in scientific research.

It acts as a potent 5-HT6 receptor partial agonist, with a Ki of 1 nM, a significantly higher affinity than older 5-HT6 agonists such as EMDT, although it possesses moderate affinity for the 5-HT3 receptor as well.

[1] Subsequent research has determined that EMD-386088 is also a dopamine reuptake inhibitor and that this action is involved in the antidepressant-like effects of the drug in rodents.

[2] EMD-386088 can be further reacted with a butyrophenone sidechain.

[3] This drug article relating to the nervous system is a stub.