AL-34662 is an indazole derivative drug that is being developed for the treatment of glaucoma.

[1] The serotonin 5-HT2A receptor is the same target as that of psychedelic drugs like psilocin.

This means that AL-34662 can exploit a useful side effect of the hallucinogenic 5-HT2A receptor agonists, namely reduction in intra-ocular pressure and hence relief from the symptoms of glaucoma, but without causing the psychedelic effects that make centrally active serotonin 5-HT2A receptor agonists unsuitable for clinical use.

[3] Peripherally acting 5-HT2A agonists have been a rich field of research in recent years, with potential glaucoma treatments being the main proposed application for serotonin 5-HT2A receptor agonists at present, as centrally acting agonists for this receptor tend to be hallucinogenic and thus their medical usefulness is currently limited to the treatment of psychiatric disorders.

While many novel, potent, and selective serotonin 5-HT2A receptor agonists have been developed for this application,[4][5][6][7][8][9][10][11] retaining peripheral selectivity can be a problem, and several of the more lipophilic compounds closely related to AL-34662 such as those shown below, did cross the blood–brain barrier and produced hallucinogen-appropriate responding in animals.