The protein is found in rodents, but not in humans, because stop codons in the gene's coding sequence prevent the gene from expressing a functional protein.

[6] 5-HT5B receptor mRNA is expressed primarily in the habenula, hippocampus and inferior olive of rat brains.

[7] Known agonists for 5-HT5B include ergotamine and LSD.

Known antagonists include methiothepin.

This transmembrane receptor-related article is a stub.