[4] Piperazines were originally named because of their chemical similarity with piperidine, part of the structure of piperine in the black pepper plant (Piper nigrum).

[7] The piperazine is separated from the product stream, which contains ethylenediamine, diethylenetriamine, aminoethylpiperazine and other related linear and cyclic chemicals of this type.

Piperazines, especially BZP and TFMPP were extremely common adulterants in the club and rave scene, often being passed off as MDMA, although they do not share many similarities in their effects.

One or more of piperazine's performance advantages are often compromised in practice due to its low concentration; nonetheless, the CO2 absorption rate, heat of absorption, and solvent capacity are increased through the addition of piperazine to amine gas treating solvents, the most common of which is MDEA due to its unmatched high rate and capacity efficiency.

For example, a 5 m PZ/5 m MDEA blend yields an 11% larger difference in CO2 concentration than 8 m PZ between the lean (inlet absorbent) and rich (outlet absorbent) amine solvent streams, or in other words, more CO2 is removed from the sour (flue) gas stream per unit mass of solvent, and an almost 100% larger concentration difference than 7 m MEA.

[13] The advantages to using concentrated piperazine (CPZ) as an additive had been confirmed through, for example, three pilot plants in Australia that are operated by CSIRO.

Using CPZ, which is more reactive and thermally stable than standard MEA solutions, capital and compression (energy) costs were lowered through size reductions in absorber columns and solvent regeneration at higher temperatures.

[15] Other examples include:[16] Antianginals Antidepressants Antihistamines Antiserotonergics Antipsychotics Recreational Drugs Urologicals Others Most of these agents can be classified as either phenylpiperazines, benzylpiperazines, diphenylmethylpiperazines (benzhydrylpiperazines), pyridinylpiperazines, pyrimidinylpiperazines, or tricyclics (with the piperazine ring attached to the heterocyclic moiety via a side chain).