Tetracyclic antidepressant

Drugs that contain four rings not all fused together but are sometimes still classified as TeCAs include: Drugs that contain four rings not all fused together but could still be classified as tetracyclic include: Drugs that contain four rings not all fused together but could still be classified as tetracyclic include: TeCAs have diverse pharmacology and differ from TCAs in a number of ways.

With the exception of amoxapine, TeCAs do not inhibit the reuptake of serotonin[citation needed].

Conversely, whereas TCAs have relatively low affinity for the α2-adrenergic receptor, mianserin and mirtazapine potently antagonize this receptor, and this action is thought to be involved in their antidepressant effects[citation needed].

On the other hand, in contrast to almost all TCAs, TeCAs have only low affinity for the muscarinic acetylcholine receptors, and for this reason, are associated with few or no anticholinergic side effects[citation needed].

[1][2] The binding profiles of various TeCAs in terms of their affinities (Ki, nM) for various receptors and transporters are as follows:[3] The TeCAs act as antagonists or inverse agonists of the receptors and as inhibitors of the transporters.