5-MeO-DET or 5-methoxy-N,N-diethyltryptamine is a hallucinogenic tryptamine.

5-MeO-DET inhibits serotonin reuptake with an IC50 value of 2.4 μM and activates 5-HT2A receptors with an EC50 value of 8.11 nM.

[1][2][3][4][5][6][7] Low dosages (0.5–1 mg) are reported to produce a relaxing body high and mild entheogenic effects.

Shulgin reports in TiHKAL that higher dosages (1–3 mg) can produce very unpleasant reactions.

This hallucinogen-related article is a stub.