The regiment was attached to 15th Brigade, 4th Division, Army of the Ohio, to June 1862.
2nd Brigade, District of Jackson, Tennessee, XVI Corps, to March 1863.
October 25, 1861: Moved to New Albany, Indiana December 25: Bardstown, Kentucky February 1862: Advanced on Bowling Green, Kentucky February 10-March 3: Advanced on Nashville, Tennessee until September 1862: Guard duty along Louisville & Nashville Railroad July 4–28: Operations against Morgan August 20: Pilot Knob, Drake’s Creek, Manscoe’s (Mansker’s) Creek (Companies C, E, I, K) September 14–17: Siege of Munfordville, Kentucky (Companies A, B, D, F, and H) September 17: Captured until November: Paroled and sent to Indianapolis, Indiana (and duty there) November 1–10: Moved to Jackson, Tennessee December 18, 1862 to January 3, 1863: Operations against Forrest in western Tennessee December 29–30: Huntington December 30: Parker's Cross Roads, near Jackson December 30: Clarksburg (detachment).
December 31: Red Mound (or Parker's) Cross Roads until August 1863: Duty at Jackson, Collierville and Memphis, Tennessee August 28: Moved to Helena, Arkansas September 1–10: Steele's Expedition to Little Rock September 10: Bayou Fourche and capture of Little Rock until March 1864: Garrison duty at Lewisburg, Arkansas March 2, 1864: Reenlisted March 23-May 3: Steele's Expedition to Camden April 2: Antoine and Terre Noir Creek April 9–12: Prairie D'Ann April 15: Camden April 15–16: Liberty Post Office April 16–18: Camden April 17: Red Mound April 30: Jenkins' Ferry, Saline River until July: Duty at Little Rock until December: non-veterans duty at Little Rock July–August: Veterans absent on furlough until January 1865: Duty at Little Rock January 22-February 4: Carr's Expedition to Saline River February 1865: Moved to Mobile Point, Alabama March 17-April 12: Campaign against Mobile and its defenses .
March: Siege of Spanish Fort and Fort Blakely April 9: Assault and capture of Fort Blakely April 12: Capture of Mobile April 13: Whistler's Station April 13–22: March to Montgomery May 25, 1865: Merged with the 52nd Indiana Infantry Regiment The regiment lost a total of 218 men during service; 3 officers and 54 enlisted men killed or mortally wounded, 3 officers and 158 enlisted men died of disease.