[2][4] It can be produced from isoxanthohumol in fungal cells cultures,[5] and by flora in the human intestine.

[1][6] 8-PN was shown to preserve bone density[1] and has been demonstrated to reduce hot flashes.

[1][2][9] This prenylflavanoid has drawn interest in the study of hormone replacement therapy, and it is comparable to some selective estrogen-receptor modulators.

[14] More recently, a radioligand binding study showed enhancements in GABAA receptor activity by 8-PN[15] Prenylflavonoids from hops, including 8-PN, are ingredients in some breast enlargement supplements,[16] though there is no evidence of its effectiveness for this purpose.

[18] There is another compound, 8-isopentenylnaringenin,[1] also known as sophoraflavanone B, from Sophora flavescens, that could properly be called 8-prenylnaringenin by scientific naming convention.