[2] High consumption of dietary naringenin is generally regarded as safe, mainly due to its low bioavailability.

[2] Taking dietary supplements or consuming grapefruit excessively may impair the action of anticoagulants and increase the toxicity of various prescription drugs.

[2] Similar to furanocoumarins present in citrus fruits, naringenin may evoke CYP3A4 suppression in the liver and intestines, possibly resulting in adverse interactions with common medications.

Like the majority of flavanones, naringenin has a single chiral center at carbon 2, although the optical purity is variable.

Cunninghamella elegans, a fungal model organism of the mammalian metabolism, can be used to study the naringenin sulfation.