80 South Street was a proposed residential skyscraper in the Financial District of Manhattan, New York City, that had been planned in the early 21st century.

The original proposal for the skyscraper, released in 2003, was designed by renowned Spanish architect Santiago Calatrava, and was canceled in 2008 as a result of a declining real-estate market.

A new shorter design was planned to be finished in 2016, and China Oceanwide Holdings Limited acquired 80 South Street in March 2016.

The existing building, including the side door entrance on Fletcher Street, was used as the set for API headquarters in the short-lived AMC series Rubicon, filmed in 2010.

The design of the building consisted of 12 four-story cubes stacked on top of one another, cantilevered off a central concrete column standing above an 8-story base.

The design was based on plans by China Oceanwide Holdings Limited, which had already disengaged from the project and sold the building site.