The A4130 is a British A road which runs from a junction with the A404 at Burchetts Green (Maidenhead), Berkshire to the A417 at Rowstock in Oxfordshire.

It passes through Henley-on-Thames, and Nettlebed, and bypasses Wallingford and Didcot.

A few years later, a new link road was built from Didcot to Milton Heights and became the A4130.

Until 1990 the road started at a junction with the A423 1.2 miles (1.9 km) west of Nuffield, and the 2.5-mile (4.0 km) stretch between that point and Crowmarsh Gifford was designated a trunk road.

When the M40 motorway was opened, the A423 and the A4130 both lost trunk road status because the route from Maidenhead to the Coventry was transferred onto the M40.