The A4216 is a main road in Swansea, Wales.

The road links Sketty with Gendros.

It begins at the junction at the bottom of Sketty Lane with Mumbles Road.

It continues up Sketty Lane, onto Sketty Park Road then bears right onto Dillwyn Road to the junction with the A4118 (Gower Road) at Sketty Cross.

The only dual carriageway section is along Sketty Lane.