The A72 road is a major route in Scotland connecting Hamilton in South Lanarkshire, with Galashiels in the Scottish Borders.

It travels for over 97 kilometres (60 mi) in a south-easterly direction, along the Clyde and Tweed valleys, passing the towns of Larkhall, Lanark, Biggar and Peebles.

Starting at the junction with the A724, the road parallels the M74, following the original A74 (now B7078) before descending into the forested Clyde Valley as it skirts around the town of Larkhall.

The road follows the River Clyde, with some tight bends, sheer drops and adverse cambers, and meets the A73 just north of Lanark.

This section of road is notorious for accidents due to its high elevation, poor weather and winding route.