1UGV2309271302ENSG00000145819ENSMUSG00000036452Q9UNA1Q6ZQ82NM_001135608NM_015071NM_001349547NM_175164NM_001361073NM_001374831NP_001129080NP_055886NP_001336476NP_780373NP_001348002NP_001361760Rho GTPase activating protein 26 (ARHGAP26) also known as GTPase Regulator Associated with Focal Adhesion Kinase (GRAF) is a protein that in humans is encoded by the ARHGAP26 gene.

[8] By virtue of an N-terminal BAR domain, GRAF1 sculpts the endocytic membranes of this pathway into 40 nm diameter tubules and vesicles that allow uptake of extracellular fluid, GPI-linked proteins and certain bacterial exotoxins into cells.

There are several members of the GRAF family of proteins, including GRAF2, GRAF3, and oligophrenin, all of which likely playing similar roles during clathrin-independent endocytic events.

Mutations of both GRAF1 and oligophrenin are strongly implicated in causing human disease (leukaemia and mental retardation, respectively).

Recently, autoantibodies to ARHGAP26 have been implicated in autoimmune cerebellar ataxia.