1HTJ, 1XCG, 2DLS, 3KZ1, 3T06, 5E6P9826213498ENSG00000132694ENSMUSG00000041977O15085n/aNM_014784NM_198236NM_001377418NM_001377419NM_001003912NM_001360195NM_001360197NP_055599NP_937879NP_001364347NP_001364348n/aRho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 gene.

Rho guanine nucleotide exchange factor 11 is guanine nucleotide exchange factor (GEF) for the RhoA small GTPase protein.

[8] Rho is a small GTPase protein that is inactive when bound to the guanine nucleotide GDP.

[9] In particular, active Rho is a major regulator of the cell actin cytoskeleton.

This action increases the rate of G protein deactivation, limiting the time during which these RhoGEFs activate Rho.