[5][6][7] This protein is also called AKAP-Lbc because it encodes the lymphocyte blast crisis (Lbc) oncogene, and ARHGEF13/RhoGEF13 because it contains a guanine nucleotide exchange factor (GEF) domain for the RhoA small GTP-binding protein.

A-kinase anchor protein 13/Rho guanine nucleotide exchange factor 13 is guanine nucleotide exchange factor (GEF) for the RhoA small GTPase protein.

[8][9] Rho is a small GTPase protein that is inactive when bound to the guanine nucleotide GDP.

The AKAP13 gene encodes a member of the AKAP family since the protein binds tightly to PKA, especially in the heart.

Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms.