1TXD, 1X86, 2OMJ, 2OS62336569632ENSG00000196914ENSMUSG00000059495Q9NZN5Q8R4H2NM_001198665NM_001301084NM_015313NM_027144NM_001359232NP_001185594NP_001288013NP_056128NP_081420NP_001346161Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene.

[5][6][7] This protein is also called RhoGEF12 or Leukemia-associated Rho guanine nucleotide exchange factor (LARG).

[5] Rho is a small GTPase protein that is inactive when bound to the guanine nucleotide GDP.

This action increases the rate of G protein deactivation, limiting the time during which these RhoGEFs activate Rho.

[12] This protein is observed to form myeloid/lymphoid fusion partner in acute myeloid leukemia.