1UJY, 1WYR945973341ENSG00000129675ENSMUSG00000031133Q15052Q8K4I3NM_001306177NM_004840NM_152801NM_001358573NP_001293106NP_004831NP_001392100NP_001392101NP_001392102NP_001392103NP_001392104NP_001392105Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene.

[8] αPIX shares this domain structure and signaling function with the highly similar ARHGEF7/βPIX protein.

αPIX contains a central DH/PH RhoGEF domain that functions as a guanine nucleotide exchange factor (GEF) for small GTPases of the Rho family, and specifically Rac and Cdc42.

In the case of αPIX, its SH3 domain binds to partner proteins with appropriate polyproline motifs, and particularly to group I p21-activated kinases (PAKs) (PAK1, PAK2 and PAK3).

αPIX contains an amino-terminal Calponin Homology (CH) domain whose functions remain relatively poorly defined, but interacts with parvin/affixin family proteins.