On his own, he has had four platinum albums and four Top 10 hits in the United States, including three that reached number one on Billboard's Adult Contemporary chart.

In 1989, Neville teamed up with Linda Ronstadt on the album Cry Like a Rainstorm, Howl Like the Wind which included four duets by the pair.

[3] Following the success of Cry Like a Rainstorm, Howl Like the Wind, Ronstadt produced his 1991 album Warm Your Heart[4] including the hit single "Everybody Plays the Fool", a cover of the 1972 Main Ingredient song, which reached No.

Warm Your Heart was certified platinum in 1997 for more than a million sales in the U.S.[6] During 1993 and 1994, Neville expanded his repertoire as a recording artist and ventured into making country music.

The follow-up single "The Grand Tour", a cover of country music legend George Jones' 1974 hit, peaked at No.

In April 1994, Neville appeared on Sesame Street to sing the song "I Don't Want to Live on the Moon" as a duet with Ernie.

Neville sang the US national anthem in the movie The Fan starring Robert De Niro and Wesley Snipes.

Neville sang the theme music to the children's TV series Fisher-Price Little People and the songs for the sixth volume, "Discovering Seasons."

In 1988 he recorded "Mickey Mouse March" for Stay Awake: Various Interpretations of Music from Vintage Disney Films, one of Various Artists.

In 2006, Neville performed a rendition of "The Star-Spangled Banner", alongside Aretha Franklin and Dr. John on keyboards at Super Bowl XL in Detroit, Michigan.

In addition, Neville (along with brothers Art and Cyril) did background vocals for the songs "Great Heart", "Bring Back the Magic", "Homemade Music", "My Barracuda", and "Smart Woman (in a Real Short Skirt)" on Jimmy Buffett's Hot Water, released in 1988.

Zion Mass Choir, released a version of the song "A Change Is Gonna Come" on the compilation album Oh Happy Day.

[16] Neville was the featured artist for the 100th Anniversary Celebration of the University of Memphis Centennial Concert September 30, 2011, at the Cannon Center for the Performing Arts.

[18] In January 2013, paying tribute to the songs of his youth, Blue Note Records released Neville's My True Story, a collection of 12 doo-wop tunes, produced by Don Was and Keith Richards, with backing by musicians such as Benmont Tench and Tom Petty and the Heartbreakers.

[23] His uncle, George "Big Chief Jolly" Landry, was lead singer of the Mardi Gras Indian group the Wild Tchoupitoulas.