[2][3] In 1980s Memphis, Tennessee, the Le Bonheur Children's Medical Center formed two companies to distribute drugs to the American Southeast, Nova Factor and Southern Health Systems (SHS).

[1] Accredo offers "Therapeutic Resource Centers" (TRCs) for specialty conditions, such as asthma, cystic fibrosis, HIV, multiple sclerosis and rheumatoid arthritis.

[10][11][12] Side effect management is an important part of TRCs, as they are a large contributor to patients not complying with their drug regimens.

[12] The company's Clinical Day Supply program addresses patient noncompliance with oral oncology drug regimens.

[14][15][16] A 2019 investigation by Olga Khazan in The Atlantic documented how Accredo and other specialty pharmacies harm patients in their efforts to cut costs as they delay sending medications for weeks and, at times, months.