Acetohexamide (trade name Dymelor) is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2, particularly in people whose diabetes cannot be controlled by diet alone.

This inhibits the outflux of potassium, which causes the membrane potential to become more positive.

This depolarization in turn opens voltage-gated calcium channels.

The rise in intracellular calcium leads to increased fusion of insulin granulae with the cell membrane, and therefore increased secretion of insulin.

This drug article relating to the gastrointestinal system is a stub.