It can arise de novo or may develop in patients having the chronic form of a hypereosinophilic syndrome.
Patients with acute eosinophilic leukemia have a propensity for developing bronchospasm as well as symptoms of the acute coronary syndrome and/or heart failure due to eosinophilic myocarditis and eosinophil-based endomyocardial fibrosis.
A specific histochemical reaction, cyanide-resistant peroxidase, permits identification of leukemic blast cells with eosinophilic differentiation and diagnosis of acute eosinoblastic leukemia in some cases of AML with few identifiable eosinophils in blood or marrow.
[4] with this gene fusion and eosinophilic cytokine comes under control of immunoglobulin heavy chain (IgH) locus.
Overall prognosis is not dependent on eosinophilia but underlying lineage and genetic abnormalities.