[1] Signs and symptoms may include weight loss, fever, malaise, cough, skin and mucosal lesions, diarrhea, and peripheral neuropathy.
[5] For a diagnosis of CEL, hypereosinophilia with greater than 30% eosinophils is required.
In cases associated with PDGFRB, serum vitamin B12 and tryptase may be elevated.
[2] CEL associated with a mutation in PDGFRA is treatable with imatinib and has an excellent prognosis.
[4] Progression can occur from CEL to AEL or AML in rare cases.