Stem cell factor expression is increased in some cases, and solitary cutaneous mastocytomas have been reported at trauma sites.

The diagnosis of solitary mastocytoma is primarily clinical, with skin biopsy confirming a KIT mutation and mast cell infiltration.

Solitary mastocytoma usually presents as an indurated, erythematous, round or oval, yellow-brown or reddish-brown, papule, plaque, or nodule, typically measuring 1 to 5 cm in diameter.

[5] It normally develops larger for a few months, then for a variable amount of time grows in accordance to the patients size before gradually shrinking.

[15][16] It has been demonstrated that in solitary cutaneous mastocytomas, melanocyte stimulation results in elevated local concentrations of soluble mast cell growth factors.

[8] Based on the lesion's shape, the existence of a positive Darier sign, and the lack of systemic involvement, the diagnosis is primarily clinical.

[20] Using air conditioning in hot weather, bathing in lukewarm water, and removing or avoiding triggers are examples of preventative methods.