Acylsilane

Acylsilanes are a group of chemical compounds sharing a common functional group with the general structure RC(O)-SiR3.

[1] Acylsilanes can be synthesized by treating acyl anion equivalents with silyl halides (typically trimethylsilyl chloride, tmsCl).

Silylation of 2-lithio-1,3-dithiane, followed by hydrolysis of the dithioacetal group with mercury(II) chloride.

Several approches to acylsilanes start with carboxylic acid derivatives.

[1] Esters undergo reductive silylation en route to acylsilanes: Tertiary amides react with silyl lithium reagents: Acid chlorides are converted using hexamethyldisilane: Some acyl silanes are prepared by oxidation of a suitable silanes.