He attended Dorman High School in Roebuck, South Carolina and played varsity football and basketball for the Cavaliers.

Humphries went undrafted in the 2015 NFL draft, but accepted an invitation to attend rookie minicamp with the Tampa Bay Buccaneers.

[6] He entered training camp competing to be the Buccaneers' fifth wide receiver on their depth chart with Robert Herron, Donteea Dye, Rannell Hall, Tavarres King, and Kaelin Clay.

[7] On September 6, 2015, it was announced that Humphries had made the 53-man roster and would be a punt/kick returner and the Buccaneer's fifth wide receiver behind veterans Vincent Jackson, Mike Evans, Louis Murphy, and Russell Shepard.

[8][9] Humphries made his NFL debut in the Buccaneers' season opener against the Tennessee Titans and finished the loss with two receptions for 14 yards.

[11] After injuries to Buccaneer wide receivers Vincent Jackson and Russell Shepard, it was announced on October 28, 2015, that Humphries and Donteea Dye had been added to the active roster.

[12] On December 13, 2015, Humphries caught his first career touchdown reception on a six-yard pass from Jameis Winston, during a 24–17 loss to the New Orleans Saints.

[15] Humphries entered training camp competing with Russell Shepard and Kenny Bell to be the Buccaneers' third wide receiver under new head coach Dirk Koetter.

During a Week 9 matchup against the Falcons, he caught five receptions for 46 yards and his first touchdown of the season on a seven-yard pass from Jameis Winston during a 43–28 loss.

[30][31] During a Week 10 35–32 victory against the Kansas City Chiefs, he caught his first touchdown of the season on a 23-yard reception from Ryan Tannehill, which proved to be the game-winner.