The 2018 season was the Carolina Panthers' 24th in the National Football League (NFL) and their eighth under head coach Ron Rivera.

After starting 6–2, the Panthers suffered a late-season collapse, going on a 7-game losing streak, failing to improve or match their previous season's record, and were eliminated from playoff contention following a loss to the Atlanta Falcons in Week 16.

Although they went a dismal 1–7 in the second half of the season, the Panthers managed to end on a high note by defeating their division rival New Orleans Saints, 33–14.

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Alexander Armah scored a touchdown in the fourth quarter, but the extra point attempt was no good when the ball slipped out of Michael Palardy's hands.

Tight end Greg Olsen and offensive tackle Daryl Williams left the game early due to injuries.

The Bengals were the first to score in the game but the Panthers answered back with a Cam Newton touchdown.

Late in the first quarter Andy Dalton threw a pass intended for John Ross but it was intercepted by Donte Jackson.

Early in the second Devin Funchess scored a touchdown with a Graham Gano field goal, and Carolina took the lead.

Dalton's Hail Mary attempt, intended for Tyler Eifert, was picked off by Luke Kuechly.

In the fourth quarter, the Giants scored a touchdown with a two point conversion, followed by a Carolina field goal.

With 1:15 to go in the game, the Giants scored on a Saquon Barkley touchdown catch, giving New York their first lead since the first quarter.

It was the longest successful field goal in franchise history and Gano became one of only six players to make a kick from 63 yards or longer.

However, on fourth down and 5 at the Redskins 16, Cam Newton's pass for Jarius Wright fell incomplete.

With two seconds to go in the half, Graham Gano kicked a field goal, giving Carolina a 24–7 lead.

In this Thursday night game, the Steelers were too much for the Panthers, as the Steelers' defense sacked Cam Newton five times and returned an interception for a touchdown, while their offense scored on seven of their eight drives under Ben Roethlisberger, who threw for five touchdowns and recorded a perfect passer rating, culminating in a 21–52 loss.

Cam Newton went 23 for 29, throwing for 193 yards, 2 touchdowns, and 1 interception, giving him a passer rating of 103 in spite of the Steelers suffocating defense.

Carolina's defense stifled Drew Brees and the Saints offense for most of the game, forcing three turnovers.

Cornerback Donte Jackson had a pick-two on a two-point conversion attempt and fellow corner James Bradberry had an interception.

During the week, the Panthers decided to give backup QB Taylor Heinicke his first NFL start due to Newton's injured shoulder.