Adhyperforin is a phytochemical found in the members of the plant genus Hypericum including St. John's Wort.

[1] It has a very similar pharmacological profile to hyperforin and acts as a TRPC6 ion channel activator,[1] thereby inhibiting the reuptake of various neurotransmitters including serotonin, norepinephrine, dopamine, GABA, and glutamate.

[1] Adhyperforin is found in St. John's Wort in levels approximately 1/10 those of hyperforin.

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