Being a first team regular in 2010, Mehmedi established himself as a physical striker, excellent in the box as well as having a good turn of pace, he was also technically great.

[5] On 26 May 2014, Freiburg decided to buy Mehmedi for a reported €6 million after having a good season, scoring 12 goals in 32 games during his loan spell with the Bundesliga side.

[9] At the end of the 2022–23 season, the forward terminated his contract with the club by mutual consent;[10] on 30 August 2023, he publicly announced his retirement from professional football, citing his desire to spend more time with his family and pursue a coaching career as the main reasons behind his decision.

[12] Mehmedi made his debut for the Swiss national team against England, in a UEFA Euro 2012 qualifying match, coming on as a substitute.

[13] On 15 June 2014, he replaced Valentin Stocker at half time in Switzerland's opening 2014 FIFA World Cup match against Ecuador.

[16][17] Following his participation in Switzerland's UEFA Euro 2020 campaign, in which they reached the quarter-finals for the first time, Mehmedi officially announced his retirement from the national side on 16 July 2021.