He served as Deputy Minister of Productive Activities with delegation to foreign trade in the second and third governments headed by Silvio Berlusconi.

After joining Gianfranco Fini's new party, Future and Freedom, Urso, along with other representatives Andrea Ronchi, Roberto Menia, and Antonio Buonfiglio, as well as Giuseppe Maria Reina of the Movement for Autonomy, resigned on 15 November 2010 and left the government due to the refusal by Berlusconi to resign and form a new government open to the Union of the Centre, as had been requested by Fini.

[1] On 19 April 2011, Urso founded the association FareItalia and on 9 July 2011, together with Andrea Ronchi and Giuseppe Scalia, he definitively left Future and Freedom.

[2][3] In 2015, Urso joined Brothers of Italy, a party led by Giorgia Meloni, and in 2018 was elected senator into its lists.

[4] In April 2024, Urso, as an industry minister, met with representatives of Uber to discuss the company's position in the country.