He was offered a tryout from the Buffalo Bills and was signed a future/reserve contract in May 2015, although coach Rex Ryan admitted his chances of making the roster were a longshot.

[8] He played in 16 games with four starts in 2017 in place of the injured Greg Olsen, recording two catches for 17 yards.

[9] In Week 15 of the 2018 season, Manhertz caught his first career touchdown on a trick play 50-yard pass from running back Christian McCaffrey.

[10] On January 29, 2019, Manhertz signed a two-year contract extension with the Panthers and was named the starter for the 2020 season.

[12] During a Week 1 game against the Houston Texans, Manhertz caught a 22-yard touchdown pass from rookie quarterback Trevor Lawrence.