223214149ENSG00000161513ENSMUSG00000018861P22570Q61578NM_004110NM_024417NM_007997NP_004101NP_077728NP_032023Adrenodoxin reductase (Enzyme Nomenclature name: adrenodoxin-NADP+ reductase, EC 1.18.1.6), was first isolated from bovine adrenal cortex where it functions as the first enzyme in the mitochondrial P450 systems that catalyze essential steps in steroid hormone biosynthesis.

[5][6] Examination of complete genome sequences revealed that adrenodoxin reductase gene is present in most metazoans and prokaryotes.

In the human gene nomenclature, the standard name is ferredoxin reductase and the symbol is FDXR, with ADXR specified as a synonym.

[13] Adrenodoxin functions as a mobile shuttle that transfers electrons between ADXR and mitochondrial P450s.

[19][7] The location of these FAD and NADP binding sites were confirmed by the crystal structure of the enzyme.