Adrianus van Kleffens (14 October 1899 – 2 Augustus 1973) was a Dutch civil servant and judge.
His older brother was Eelco van Kleffens, who would later become a noted diplomat and Minister for Foreign Affairs.
In 1934 he attained a position as director of the External Trade department of the Dutch Ministry for Economic Affairs.
After the war had ended in 1945 he went to work at the same Ministry once more, he focused on European economic integration.
After his time at the Ministry he became one of the first judges of the European Court of Justice, he served together with fellow Dutchman Jos Serrarens.