[6] The initial location was a three-story building owned by the publisher of the local newspaper, the Star–Banner, which was leased to the new hospital until 1901.

Munroe, a local banker,[8] who gathered community support and led the push to expand the hospital.

[11][12] On August 1, 2018, Adventist Health System acquired Munroe Regional Medical Center and its TimberRidge ER.

[14][15] On January 1, 2021, the United States government passed a law requiring all hospitals to have their chargemaster on its website.

[18][19] In July and August 2022, AdventHealth Ocala was sued by five nurses who alleged false imprisonment and emotional distress during an active shooter drill in November 2021.

The lawsuits allege that during a Disaster Preparedness and Mass Casualty training session[20] an AdventHealth Ocala employee posed as a gunman at the direction of hospital management, simulated gunfire, told the nurses to lay on the ground and demanded drugs.

[21] Two of the nurses claim that they were being treated for post-traumatic stress disorder as a result of the events they experienced during the drill.