Huguley is named after Herbert T. Huguley, a dentist and a real estate investor of Dallas, Texas who left his $6 million estate to the Seventh-day Adventist Church for the building of a hospital in honor of his parents.

[3][1] In February 1977, Hugeley Memorial Medical Center opened by Interstate 35,[1][3] it was one of the first hospitals in the United States to have all private rooms.

[3][5] On May 16, 2014, construction workers from The Beck Group began building a six-story, 234,000-square-foot hospital with 140 spacious beds to replace the older one.

[4][7] On August 7, 2016, the new Texas Health Huguley Hospital Fort Worth South opened west of the older building.

[1][9][10] On January 24, 2024, Texas Health Huguley Hospital Fort Worth South had a ribbon cutting cermony for its new patient tower.