Soon after the Florida Department of Environmental Protection ordered Memorial Hospital-Flagler that both of its underground fuel tanks had to be taken off of its property.

[8][9] In September 2002, Memorial Hospital-Flagler moved to Palm Coast and was renamed Florida Hospital Flagler.

[11][12][13] In July 2011, Florida Hospital Flagler purchased 3 acres in the Cobblestone Village located by Golden Corral.

[19][20][21] In early December 2012, Kangaroo Express donated $110,000 to Florida Hospital Pink Army for its fight against breast cancer.

[22][23] On August 1, 2013, during a special meeting Flagler County commissioners voted 4-to-1 to purchase the former Memorial Hospital-Flagler for $1.23 million.

[29][30][31] In late January 2016, Florida Hospital Flagler announced that it would expand its cancer center by 2,000-square-feet for $4.5 million.

[42][43][44] On January 1, 2021, the United States government passed a law requiring all hospitals to have their chargemaster on its website.

[46] In September 2021, AdventHealth Palm Coast had a simulation center built by renovating some of its offices.

[47][48][49] On July 11, 2023, AdventHealth Palm Coast announced that it would have a new $30 million cancer center built on campus.

[56][57] The Freytag Cancer Center started treating patients in mid November[58] and the hospital had a grand opening for the building on January 16, 2025.

[71][72][73] In late December 2011, the hospital became the first in Florida to receive the HIMSS Analytics Stage 7 Award for its electronic health record.