It is an urban, tertiary, referral and teaching hospital whose planned construction will last five years, starting in 2020.

[3][4] The hospital is located in the neighbourhood called Nakawa, near the junction of Kampala-Jinja Highway and New Port Bell Road.

[4] It will function as the teaching hospital of Aga Khan University, Kampala, one of four campuses in East Africa, with others in Nairobi, Arusha and Dar es Salaam.

[8][9] The foundation stone for the hospital was laid by the President of Uganda and His Highness the Aga Khan on Thursday, 17 December 2015.

[12] Construction of the university campus, student hostels and an outpatient center began in April 2023, marked by a ceremony presided over by Princess Zahra Aga Khan and Janet Museveni the First Lady of Uganda and the country's mister of education.