Agglomerins are bacterial natural products, identified as metabolites of Pantoea agglomerans which was isolated in 1989 from river water in Kobe, Japan.

[1] They belong to the class of tetronate antibiotics, which include tetronomycin, tetronasin, and abyssomicin C. The members of the agglomerins differ only in the composition of the acyl chain attached to the tetronate ring.

[3] The biosynthetic gene cluster for agglomerins is 12 kb, and codes for 7 open reading frames.

The glyceryl-S-ACP and 3-oxoacyl-CoA thioester are joined by Agg1, a FabH-like ketosynthase, forming new C-C and C-O bonds.

The primary alcohol of the intermediate 4 is then acylated by Agg4, using acetyl-CoA, before the abstraction of a proton and concomitant loss of acetate catalyzed by Agg5 to generate the exocyclic double bond.