Agia Anna (Greek: Αγία Άννα) is a village and a community in the municipal unit Nileas, in northern part of the island Euboea, Greece.

The community includes the seaside village Agkali (Αγκάλι).

During winter, there are about 1000 inhabitants, with the number increasing highly during summer to around 7000 people.

After that, they found a picture of Saint Anne leading by a woman's vision.

During the Ottoman occupation of Greece, Agia Anna had been the largest and richest commune of the area, with 60 families residing there.