Agnes was a daughter of Landgrave Maurice of Hesse-Kassel (1572-1632) from his second marriage to Juliane of Nassau-Siegen (1587-1643), the daughter of Count John VII of Nassau-Siegen.

On 18 May 1623 she married Prince John Casimir of Anhalt-Dessau (1596-1660).

During the Thirty Years' War, she managed to soften the plight of Anhalt-Dessau by negotiating with the generals, both orally and in writing.

In 1645, she built a fortified house in Nischwitz, which was later developed into Oranienbaum Castle.

This article about a member of the German nobility is a stub.