He was selected with the second overall pick in the 2022 NFL draft by the Detroit Lions, and named to the All-Rookie Team in 2022.

[20][21] He finished his rookie season with 9.5 sacks, 52 total tackles (34 solo), three interceptions, three passes defensed, and two fumble recoveries.

[24] In Week 17, Hutchinson recorded three sacks against the Dallas Cowboys, marking his second consecutive season with a three-sack game.

[27] On October 13, 2024, against the Dallas Cowboys in Week 6, Hutchinson suffered a severe leg injury in the third quarter, fracturing both his tibia and fibula.

He underwent immediate surgery, with head coach Dan Campbell estimating a recovery timetable of "four to six months.

"[28] Prior to the injury, Hutchinson had recorded a league-leading 7.5 sacks and 19 total tackles in five games.