[12] Rodriguez was selected by the Detroit Lions with the 188th pick in the sixth round of the 2022 NFL draft.

[16] He finished with one sack, 87 total tackles, two passes defended, and one forced fumble.

He was named to the Pro Football Writers Association All-Rookie Team.

[18] Rodriguez made 10 appearances (6 starts) for Detroit in 2024, recording 43 combined tackles, two sacks, one pass deflection, and one fumble recovery.

On November 29, 2024, it was announced that Rodriguez would miss the remainder of the season after he suffered a torn ACL in Week 13 against the Chicago Bears.