[6] Joseph was named first-team All-Big Ten Conference in 2021 after finishing the season with 57 tackles, one sack, and three fumble recoveries while also intercepting five passes.
Dane Brugler of the Athletic projected him to be a third or fourth round pick and ranked him as the eighth best safety prospect in the draft.
[18] Throughout training camp, Joseph competed against Will Harris, Ifeatu Melifonwu, Brady Breeze, and C. J. Moore for a role as the primary backup safety.
[21] On September 11, 2022, Joseph made his professional regular season debut in the Detroit Lions' home-opener, but was limited to one tackle during their 35–38 loss to the Philadelphia Eagles.
On September 27, 2022,the Detroit Lions placed Tracy Walker on injured reserve after suffering a torn Achilles in Week 3.
He became the first player in NFL history to intercept Aaron Rodgers three times in a season, as the Lions knocked the Packers out of playoff contention.
[23] His performance earned him the National Football Conference (NFC) Defensive Player of the Week, Joseph was the first Lions rookie to win the award in franchise history.
Head coach Dan Campbell named Joseph and C. J. Gardner-Johnson the starting safety tandem to begin the season.
[31] He finished his sophomore season in 2023 with a total of 82 combined tackles (69 solo), 11 pass deflections, and four interceptions while starting all 15 games he appeared in.
On January 28, 2024, Joseph started in the NFC Championship Game and recorded six combined tackles (four solo) during a 31–34 loss at the San Francisco 49ers.
On November 3, 2024, he made four solo tackles, two pass deflections, and returned an interception thrown by Jordan Love to running back Josh Jacobs for 27-yards and scored his first career touchdown during a 24–14 victory at the Green Bay Packers.
He started all 17 games for the first time in his career and finished the 2024 NFL season with a total of 83 combined tackles (58 solo), 12 pass deflections, nine interceptions, and a touchdown.