It operated scheduled domestic services and flights to Haiti and Puerto Rico.
It wet-leased additional aircraft from Servicios Aéreos Profesionales, which it used for ad hoc, on demand charter services to the United States.
[1] It flew to certain destinations in the Caribbean, to the United States and to Puerto Rico, covering routes to John F. Kennedy International Airport and Luis Muñoz Marín International Airport with one Boeing 727-200 and one Boeing 757-200 leased from TransMeridian Airlines.
As of 2020, the airline currently undertaking expansion plans, with SAP Group handling all operations for Air Santo Domingo.
[2] As of 2021, Air Santo Domingo owns a single BAe Jetstream 32 (registered HI856) used for charter flights.