Its main base was La Isabela International Airport, Santo Domingo.

[4] IDAC later allowed the airline to recommence operations, with a reduced schedule using only two aircraft.

Caribair operated services to the following international scheduled destinations (at January 2005): Port-au-Prince and Santiago de Cuba.

Caribair flew to 26 destinations in nine countries, including Aruba, the Bahamas, Haiti, Netherlands Antilles, Jamaica, Puerto Rico, Trinidad and Tobago, Cuba, and some scheduled charter flights to the United States.

Domestics destinations included all airports in Dominican Republic, making it the largest airline of the country.