He is considered as one of the greatest exponents of Bengali classical based vocal music.
He received the first lessons in music from his maternal uncle Sri Kalidas Guha.
The childless couple devoted their life in teaching classical based vocal music to hundreds of disciples in their house located at 25, Turf Road, Bhabanipur, Kolkata.
Some of these are: ‘আজি চাঁদিনি রাতি গো’ (Aji chadini rati go), ‘ওই যে আকাশের গায়ে, দূরের বলাকা ভেসে যায়’ (Oi je akasher gaye, durer balaka vese jay), ‘শিপ্রা নদীর বুকে সন্ধ্যা নামিল হায়’ (Shipra nadir buke sandhya namil hay), ‘তোমার ভুবনে ফুলের মেলা’ (Tomar bhubane fuler mela) etc.
Kabir Suman, an artist who initiated New wave in Bengali modern songs, mentioned Akhilbandhu Ghosh in one of his compositions of 1970, বয়স আমার মুখের রেখায় (Bayas amar mukher rekhay), where it was said,[6] একলা লাগার সময় মানে নিজের সঙ্গে কথা বলা তারই ফাঁকে কোথায় যেন অখিলবন্ধু ঘোষের গলা On March 20, 1988, Akhilbandhu came back from Andal attending a musical soiree, feeling unwell.