A native of Irvington, New Jersey,[1] Muhammad attended Paterson Catholic High School in Paterson, New Jersey, but the school closed after his freshman year, and he then transferred to Don Bosco Preparatory High School in Ramsey, New Jersey, where he was a four-star defensive end, ranked as the No.

Muhammad was handed a season-long suspension for an altercation involving a former roommate after Miami's spring game; he missed the entire 2014 season.

But Muhammad missed the 2016 season after he was suspended and later dismissed from the football program along with teammate Jermaine Grace for his role in a luxury rental car scandal that violated NCAA rules.

[3] Muhammad was selected by the New Orleans Saints in the sixth round, 196th overall, in the 2017 NFL draft.

[13] In Week 10 of the 2020 season against the Tennessee Titans on Thursday Night Football, Muhammad was ejected from the game after punching offensive tackle Ty Sambrailo.