Zylstra finished his collegiate career with as Minnesota State school records of 227 catches, 4,297 receiving yards, and 54 touchdown receptions.

[6] He was elevated to the active roster on October 10, 2021, for the team's week 5 game against the Vikings.

[9] Zylstra was activated along with his brother Brandon Zylstra for Week 9 against the Green Bay Packers,[10] Shane finished with his first professional touchdown, a one-yard touchdown reception from quarterback Jared Goff.

[12] On December 24, Zylstra caught three touchdown passes during a game against the Carolina Panthers.

[13] On August 1, 2023, Zylstra was waived/injured by the Lions after suffering a knee injury in training camp, and placed on injured reserve.