[2] Initially rated as a two-star recruit, originally Moseley committed to play college football at Charlotte in the summer going into his senior year.

[4] He served mostly as a reserve defensive back during his freshman season, playing in all 13 of Tennessee's games with two starts and making 18 tackles (two for loss) and finishing second on the team with six pass breakups.

On October 19, San Francisco increased Moseley's contract from $7,600 per week to $28,235, after another team was rumored to be interested in signing him.

He made his NFL debut the same night in a 34–3 win against the Oakland Raiders, playing three snaps and notching one tackle on special teams.

In the NFC Conference Championship against the Green Bay Packers, Moseley intercepted a pass thrown by Aaron Rodgers during the 37–20 victory.

[19] In Week 7, against the New England Patriots, Moseley recorded his first interception of the season off a pass thrown by Cam Newton in a 33–6 win.

[27] He subsequently started in the next three postseason games, where the 49ers' Super Bowl run ended in an NFC Conference Championship loss to the Rams.

[28] He finished the season starting in 14 games, with 65 combined tackles (54 solo), 1 interception, 11 pass deflections and 1 fumble recovery.

[34] In Week 5 of the 2023 season, against the Panthers, Moseley returned to play, but suffered a season-ending ACL tear in his right knee.