The southern terminus of the highway is at its intersection with US 43/SR 118 at Guin.

The highway’s eastern terminus is at its intersection with SR 129 at Brilliant.

SR 44 is routed along a two-lane roadway for its entire length.

The highway serves as a connector between Guin and Brilliant, traveling through rural areas of Marion County.

Roughly 2 miles (3.2 km) before its eastern terminus, the highway has an interchange with I-22/US 78.